Searching for a photocycle of the cryptochrome photoreceptors |
| |
Authors: | Liu Bin Liu Hongtao Zhong Dongping Lin Chentao |
| |
Institution: | Department of Molecular, Cell & Developmental Biology, University of California, Los Angeles, CA 90095, USA. |
| |
Abstract: | The initial photochemistry of plant cryptochromes has been extensively investigated in recent years. It is hypothesized that cryptochrome photoexcitation involves a Trp-triad-dependent photoreduction. According to this hypothesis, cryptochromes in the resting state contain oxidized FAD; light triggers a sequential electron transfer from three tryptophan residues to reduce FAD to a neutral semiquinone (FADH*); FADH* is the presumed signaling state and it is re-oxidized to complete the photocycle. However, this photoreduction hypothesis is currently under debate. An alternative model argues that the initial photochemistry of cryptochromes involves a photolyase-like cyclic electron shuttle without a bona fide redox reaction mediated by the Trp-triad residues, leading to conformational changes, signal propagation, and physiological responses. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|