Proteins in multiple myeloma. VI. Cryoglobulins |
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| Authors: | MIYAKE A PUTNAM F W |
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| Affiliation: | 1. Department of Immunology and Rheumatology, Immunogenomics and inflammation research Unit EA 4130, University of Lyon, Lyon, France;2. Immunology Laboratory, University Hospital Lyon, France;1. Department of Internal Medicine, National Reference Center for Autoimmune Diseases, Hôpital Cochin, Assistance Publique Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France;2. Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy;3. Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy;4. Clinic of Rheumatology, Department of Medicine (DAME), ASUFC, University of Udine, Udine, Italy;5. Service de Médecine Interne et Immunologie Clinique, Centre Hospitalier Universitaire de Dijon, France;6. Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany;7. Department of Internal Medicine, CHU Timone, Assistance Publique-Hôpitaux de Marseille, Marseille, Aix-Marseille Université, France;8. Centre National de Référence des Maladies Auto-Immunes et Systémiques Rares, Est/Sud-Ouest (RESO), France, Service de rhumatologie, Centre Hospitalier Universitaire de Strasbourg, 1 avenue Molière, 67098 Strasbourg, France;9. Department of Internal Medicine, Orléans, France;10. Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d''Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;11. Service de Médecine Interne, CHRU Tours, Tours, France;12. Département de Néphrologie et Transplantation d''Organes, CHU de Toulouse, Toulouse, France;13. Department of Internal Medicine, Rheumatology and Immunology, Medius Kliniken, University of Tübingen, Kirchheim-Teck, Germany;14. Department of Dermatology, Saint-Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris;15. Department of Internal Medicine and Clinical Immunology, Regional Competence Center for Rare and Systemic Autoimmune Disease, Nancy University Hospital, Vandœuvre-lès-Nancy, University of Lorraine, UMR 7365 CNRS, IMoPA, Vandœuvre-lès-Nancy, France;p. Department of Internal Medicine, Saint-Nazaire Hospital, France;q. Département de Néphrologie and Département de Médecine Interne, Centre Hospitalier de Valenciennes, Valenciennes, France;r. Department of Medicine and Surgery, University of Milano Bicocca, and Renal Unit, ASST-Monza, Milan/Monza, Italy |
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| Abstract: | Eight cryoglobulins (abnormal human plasma globulins that have diminished solubility in the cold) have been investigated by means of the analytical ultracentrifuge, electrophoresis, N-terminal amino acid analysis, and serological classification. Although no systematic correlation among the physical constants, amino end groups, and antigenic type was apparent, all the cryoglobulins but one were closely related to normal human γ-globulin. The cryoglobulins differed most notably from normal γ-globulin and from each other in the nature of their amino end groups. In the N-terminal position, three proteins had essentially only aspartic acid, three essentially only glutamic acid, and two had both dicarboxylic acids. The hypothesis is suggested that cryoglobulins are truly unnatural proteins formed only in disease. |
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