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Sinugrandisterols A-D, trihydroxysteroids from the soft coral Sinularia grandilobata |
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| Authors: | Ahmed Atallah F Tai Shu-Hui Wu Yang-Chang Sheu Jyh-Horng |
| Institution: | a Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan b Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt c Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan d Asian Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan |
| Abstract: | Four new trihydroxysteroids, sinugrandisterols A-D (1-4), have been isolated from the CH2Cl2-soluble fraction of the EtOH extract of Sinularia grandilobata. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and 1D and 2D NMR) analysis. The cytotoxicity of 1-4 toward a limited panel of cancer cell lines is also reported. |
| Keywords: | Trihydroxysteroids Sinularia grandilobata Cytotoxicity |
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