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Antioxidant Activities of Aqueous Extract from Cultivated Fruit-bodies of Cordyceps militaris (L.) Link In Vitro
作者姓名:Yu  Zhan  Cai-Hong  Dong  Yi-Jian  Yao
作者单位:[1]Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, the Chinese Academy of Sciences, Beijing 100080, China; [2]Graduate University of the Chinese Academy of Sciences, Beijing 100049, China
基金项目:Supported by the National Natural Science Foundation of China (30025002), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-SW-101C), and the Scheme of Introduction of 0verseas 0utstanding Talents, the Chinese Academy of Sciences.
摘    要:Biological antloxldants extracted from plants and fungi have potential abilities to scavenge free radicals and Inhibit lipid peroxldatlon, playing Important roles in preventing diseases, for example, cancer, and aging Induced by reactive oxygen species, which may cause oxidative damage to DNA, proteins and other macromolecules. The antloxldant potency of cultivated fruit-bodies of Cordyceps militarls (L.) Link was investigated In this study. Five established In vitro systems were employed, including the 1,1-dlphenyl-2- plcryldrazyl (DPPH) free radical scavenging, hydroxyl radical eliminating, iron chelating, Inhibition of Ilnolelc acid lipid peroxldatlon and reducing power. The aqueous extract from cultivated fruit-bodies was subjected to the test of amino acid, polysaccharlde and mannitol. Ascorblc acid (Vc), butylated hydroxytoluene (BHT) and ethylenedlamlnetetraacetlc acid (EDTA) were used as positive controls for comparisons. Among the assays, the aqueous extract of C. mllltarls frult-bodles shows a significant scavenging effect on DPPH, eliminating the capability on hydroxyl radicals and the chelating effect on ferrous Iron. The extract also shows positive results of Inhibiting Ilnoleic acid lipid peroxldatlon and reducing power.

关 键 词:抗氧化剂  冬虫夏草  药物  药理
收稿时间:2006-04-29
修稿时间:2006-04-292006-07-07

Antioxidant Activities of Aqueous Extract from Cultivated Fruit-bodies of Cordyceps militaris (L.) Link In Vitro
Authors:Yu Zhan  Cai-Hong Dong  Yi-Jian Yao
Institution:Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, the Chinese Academy of Sciences;, Beijing 100080, China;Graduate University of the Chinese Academy of Sciences;, Beijing 100049, China)
Abstract:Biological antioxidants extracted from plants and fungi have potential abilities to scavenge free radicals and inhibit lipid peroxidation, playing important roles in preventing diseases, for example, cancer, and aging induced by reactive oxygen species, which may cause oxidative damage to DNA, proteins and other macromolecules. The antioxidant potency of cultivated fruit‐bodies of Cordyceps militaris (L.) Link was investigated in this study. Five established in vitro systems were employed, including the 1,1‐diphenyl‐2‐picryldrazyl (DPPH) free radical scavenging, hydroxyl radical eliminating, iron chelating, inhibition of linoleic acid lipid peroxidation and reducing power. The aqueous extract from cultivated fruit‐bodies was subjected to the test of amino acid, polysaccharide and mannitol. Ascorbic acid (Vc), butylated hydroxytoluene (BHT) and ethylenediaminetetraacetic acid (EDTA) were used as positive controls for comparisons. Among the assays, the aqueous extract of C. militaris fruit‐bodies shows a significant scavenging effect on DPPH, eliminating the capability on hydroxyl radicals and the chelating effect on ferrous iron. The extract also shows positive results of inhibiting linoleic acid lipid peroxidation and reducing power. (Managing editor: Wei Wang)
Keywords:antioxidation  aqueous extract  Cordyceps militaris  free radicals  in vitro  
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