| 高血压大鼠不同血管平滑肌肌球蛋白磷酸化和脱磷酸化酶的变化 |
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| 引用本文： | Sun W,Wen YY,Wu GY. 高血压大鼠不同血管平滑肌肌球蛋白磷酸化和脱磷酸化酶的变化[J]. 生理学报, 1998, 50(1): 82-86 |
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| 作者姓名： | Sun W Wen YY Wu GY |
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| 作者单位： | 中国医学科学院基础医学研究所,中国协和医科大学基础医学院,北京,100005 |
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| 摘 要： | 本文比较了正常和高血压大鼠不同动脉血管肌球蛋白轻链激酶（ＭＬＣＫ）和依赖Ｃａ＾２＋的钙调素磷酸酶（Ｃａ＾２＋／ＣａＭ－ＰＰ）活性的变化。结果表明：在自发性高血压大鼠（ＳＨＲ）不同血管ＭＬＣＫ的活性不同,依次为主动脉（Ａ）〉尾动脉（ＣＡ）〉肠系膜动脉（ＭＡ）;而在ＷＫＹ大鼠,该酶在不同血管的活性依次为Ａ〈〈ＣＡ〈〈ＡＭ。在ＷＫＹ大鼠,ＭＡ Ｃａ＾２＋／ＣａＭ－ＰＰ活性明显高于ＳＨＲ。在肾性高血压大鼠
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| 关 键 词： | 脱磷酸化酶 高血压 肌球蛋白 轻链激酶 |
| 修稿时间： | 1996-12-02 |
Changes of activities of MLCK and dephosphatase in different arterial vessels from hypertensive rats |
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| Sun W,Wen Y Y,Wu G Y. Changes of activities of MLCK and dephosphatase in different arterial vessels from hypertensive rats[J]. Acta Physiologica Sinica, 1998, 50(1): 82-86 |
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| Authors: | Sun W Wen Y Y Wu G Y |
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| Affiliation: | Department of Physiology, Institute of Basic Medical Sciences, School of Basic Medicine, CAMS and PUMC, Beijing 100005. |
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| Abstract: | The changes of activities of myosin light chain kinase (MLCK) and Ca2+/CaM-PP in different arterial vessels from hypertensive and normotensive rats were studied. The results were as follows. The MLCK activity of different arteries of spontaneous hypertensive rats (SHR) was different with the order of aorta (A) > caudal artery (CA) > mesenteric artery (MA), while in WKY rats the order of activity among different arteries is A < CA and MA and MA Ca2+/CaM-PP is obviously higher than in SHR. In renal hypertensive rats the activities of Ca2+/CaM-PP in different arteries are not quite different from those of the Wistar rats. The above results suggest that higher activities of MLCK or/and lower activity might be related to vasocontraction and hypertension. |
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| Keywords: | hypertensive rat myosin light chain kinase Ca2 /CaM-dependent protein phosphatase |
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