Atherosclerosis decreased prostacyclin formation in rabbit lungs and kidneys |
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| Authors: | Aldona Dembi&#x ska-Kie&#x , Werner Rü cker,Peter S. Sch nh fer |
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| Affiliation: | Department für Pharmakologie und Toxikologie, Abt. II, Medizinische Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000 Hannover 61, (GFR) Germany |
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| Abstract: | Metabolism of arachidonic acid (AA) was studied in perfused lungs and kidneys of normal and atherosclerotic rabbits by determination of PGE2, PGF2α and the stable metabolites of PGI2 (6-keto-PGF1α) and TXA2 (TXB2). PGI2 was the main AA metabolite formed by normal lungs and kidneys. Atherosclerosis reduced the formation of PGI2 by about 50 % in both organs. TXA2 formation was similarily decreased in lungs. In kidneys, the decrease in PGI2 formation was accompanied by an increase in PGE2 formation. |
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