Release of PGF(2alpha) during parturition and the postpartum period in the ewe |
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Authors: | Fredriksson G |
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Institution: | Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Agricultural Sciences, S-750 07 Uppsala, Sweden. |
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Abstract: | Peripheral plasma levels of 15-keto-13, 14-dihydro-PGF(2alpha) were determined from one week before parturition until five weeks postpartum in six ewes. Starting at approximately 1 nmol/l one week before parturition, the prostaglandin metabolite levels rose successively during the week preceding parturition and peaked at 70 to 125 nmol/l during parturition. During the first three days postpartum the concentrations of the 15-keto-13, 14-dihydro-PGF(2alpha) decreased to 0.5 to 1 nmol/l. These levels were maintained for three weeks and low levels of 50 to 100 pmol/l were reached around four weeks postpartum. The ewe, as well as other ruminants, has a sustained release of elevated concentrations of PGF(2alpha) postpartum. It seems likely that PGF(2alpha) plays a role in uterine involution. |
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Keywords: | ewe postpartum |
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