结直肠癌中c-erbB-2和E-cadherin蛋白表达与临床病理关系

为了探讨c-erbB-2和E-cadherin（E-cad）蛋白表达与结直肠癌浸润转移的关系及相关性.应用免疫组织化学技术,检测90例结直肠癌中c-erbB-2和E-cad蛋白表达.结果表明：90例结直肠癌中c-erbB-2和E-cad蛋白阳性表达率分别为52.2%（47/90）和46.7%（42/90）.c-erbB-2高表达及E-cad低表达与结直肠癌Dukes分期、浆膜浸润和淋巴结转移均呈正相关（P〈0.05）.结直肠癌中c-erbB-2表达与E-cad表达呈负相关（P〈0.05）.c-erbB-2和E-cad表达与结直肠癌浸润转移密切相关.联合检测其蛋白表达可作为判断结直肠癌预后的客观指标.

Relationship Between Expression c-erbB-2 and E-cadherin Protein in Colorectal Cancer and Clinical Pathological Features

To study the relationship between expression of c-erbB-2,E-cadherin(E-cad) and invasion and metastasis in colorectal cancer(CRC),and the correlation between expression of c-erbB-2 and E-cad.Immunohistochemical staining has used to detect the expression of c-erbB-2 and E-cad in 90 cases of CRC.Our results showed that the expression of c-erbB-2 and E-cad were 52.2%(47 / 90)and 46.7%(42 / 90),respectively. The high level expression of c-erbB-2 and the low level expression of E-cad were positively correlated with the Dukes staging,serosa infiltration and lymph node metastasis of CRC(P < 0.05). Positively associated with the expression of c-erbB-2 and negatively with that of E-cad(P < 0.05). These data showed a correlation between the c-erbB-2 and E-cad expression and the potential of invasion and metas-tasis in CRC. c-erbB-2 and E-cad which can be used as prognostic indicators in CRC.