<Emphasis Type="Italic">Corynebacterium glutamicum</Emphasis> as a potent biocatalyst for the bioconversion of pentose sugars to value-added products |
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Authors: | Vipin Gopinath Anusree Murali Kiran S Dhar K Madhavan Nampoothiri |
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Institution: | (1) Biotechnology Division, National Institute for Interdisciplinary Science and Technology (NIIST), CSIR, Trivandrum, 695 019, Kerala, India; |
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Abstract: | Corynebacterium glutamicum, the industrial microbe traditionally used for the production of amino acids, proved its value for the fermentative production
of diverse products through genetic/metabolic engineering. A successful demonstration of the heterologous expression of arabinose
and xylose utilization genes made them interesting biocatalysts for pentose fermentation, which are the main components in
lignocellulosic hydrolysates. Its ability to withstand substantial amount of general growth inhibitors like furfurals, hydroxyl
methyl furfurals and organic acids generated from the acid/alkali hydrolysis of lignocellulosics in growth arrested conditions
and its ability to produce amino acids like glutamate and lysine in acid hydrolysates of rice straw and wheat bran, indicate
the future prospective of this bacterium as a potent biocatalyst in fermentation biotechnology. However, the efforts so far
on these lines have not yet been reviewed, and hence an attempt is made to look into the efficacy and prospects of C. glutamicum to utilize the normally non-fermentable pentose sugars from lignocellulosic biomass for the production of commodity chemicals. |
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