(1) Applied Physics Group, MAE Department, Princeton University, Princeton, NJ, USA;(2) Kazan State Medical University, Kazan, Russia;(3) Kazan Institute of Biochemistry and Biophysics, Russian Academy of Sciences, Kazan, Russia
Abstract:
It is shown that exocytosis in a chemical synapse may be accompanied by “microjet” formation due to the overpressure that
exists in the vesicles. This mechanism may take place either at complete fusion of a vesicle with the presynaptic membrane
or in the so-called kiss-and-run mode of neurotransmitter release. A simple hydrodynamic model of the viscous incompressible
flow arising in the synaptic cleft is suggested. The occurrence of hydrodynamic flow (microjet) leads to more efficient transport
of neurotransmitter than in the case of classical diffusive transport.