Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter |
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| Authors: | Haidar Bassam Denis Maxime Marcil Michel Krimbou Larbi Genest Jacques |
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| Affiliation: | Cardiovascular Genetics Laboratory, Division of Cardiology, McGill University Health Centre/Royal Victoria Hospital, Montréal, Québec H3A 1A1, Canada. |
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| Abstract: | It has been suggested that the signal transduction pathway initiated by apoA-I activates key proteins involved in cellular lipid efflux. We investigated apoA-I-mediated cAMP signaling in cultured human fibroblasts induced with (22R)-hydroxycholesterol and 9-cis-retinoic acid (stimulated cells). Treatment of stimulated fibroblasts with apoA-I for short periods of time (
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