Fluorescence characterization of the low pH-induced change in diphtheria toxin conformation: effect of salt |
| |
Authors: | M G Blewitt J M Chao B McKeever R Sarma E London |
| |
Institution: | Laboratoire de Chimie Physiologique, Facultés Universitaires Notre-Dame de la Paix, 5000 Namur, Belgium |
| |
Abstract: | When injected into rats, a certain amount of mannitol is taken up by the liver and is associated with sedimentable structures. Isopycnic centrifugation in a sucrose gradient shows that a large part of mannitol is present in mitochondria, what remains is located in the lysosomes. The hypotonic release of mannitol present in organelles shows that the polyol is shared between mitochondria and lysosomes. The trapping of mannitol in lysosomes could result from the heterophagic or autophagic function of the lysosomes; the mechanism of its accumulation in mitochondria is still unexplained. |
| |
Keywords: | To whom correspondence should be addressed |
本文献已被 ScienceDirect PubMed 等数据库收录! |