Cytotoxic turrianes of Kermadecia elliptica from the New Caledonian rainforest |
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Authors: | Jolly Claire Thoison Odile Martin Marie-Thérèse Dumontet Vincent Gilbert Aline Pfeiffer Bruno Léonce Stéphane Sévenet Thierry Guéritte Françoise Litaudon Marc |
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Affiliation: | Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France. |
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Abstract: | In the course of an automated screening for small molecules presenting cytotoxic activity, eight new cyclophanes named kermadecins A-H (1-8), have been isolated from the bark of a New Caledonian plant, Kermadecia elliptica, Proteaceae. A LC/APCI-MS study performed on kermadecins A, B and C, provided a reliable method for the detection of other analogues existing in small quantities in the extract. This led to the isolation of five other members of this chemical series. The structures were elucidated by extensive mono- and bi-dimensional spectroscopy and mass spectrometry. The cytotoxic activity of four of them was evaluated on various cell lines. |
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Keywords: | Kermadecia elliptica Proteaceae Kermadecin Turriane Cyclophane Cytotoxicity LC/APCI-MS |
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