Chemical constituents of the plants of the genus <Emphasis Type="Italic">Cleistanthus</Emphasis> and their biological activity |
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Authors: | Paulo M M Pinho Anake Kijjoa |
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Institution: | (1) CIIMAR—Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal |
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Abstract: | Chemical examinations of Cleistanthus collinus Roxb., a poisonous tree from India, and Cleistanthus patulus Muell. Arg. have resulted in isolation of a number of arylnaphthalide lignans and their glycosides as well as some furofuranoid
lignans. While Cleistanthus gracilis Hook. f. from Thailand afforded an unusual glucoside of 2-β-hydroxy-8-azabicyclo-(5,0,2)-4β, 9β-epoxynona-5,7-diene, C. schlechteri from South Africa was the first reported source of the pimarane diterpenes. Cleistanthin A and cleistanthin B, diphyllin
glycosides isolated from C. collinus were reported to exhibit cytotoxicity on several cancer cell lines. Cleistanthin A was found to cause DNA strand breaks and
induce apoptosis in cultured cells while cleistanthin B caused G1 arrest and induced apoptosis in mammalian cells. |
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Keywords: | Anticancer activity Apoptosis Cleistanthus Lignans Pimarane diterpenes |
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