Antiischemic Effects of Topiramate in a Transient Global Forebrain Ischemia Model: A Neurochemical,Histological, and Behavioral Evaluation |
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| Authors: | Khan Shah-Naz Hayat Wright Sandra Lea Banigesh Ali Miyashita Hiro Todd Kathryn Hemmings Susan Jean Wishart Tom Shuaib Ashfaq |
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| Affiliation: | (1) Stroke Research Unit and Division of Neurosurgery, University of Saskatchewan, Saskatoon, SK, Canada;(2) Department of Psychology, University of Saskatchewan, Saskatoon, SK, Canada;(3) Department of Pharmacology, University of Saskatchewan, Saskatoon, SK, Canada;(4) Department of Psychiatry, Walter Mackenzie Health Science Centre, University of Alberta, Edmonton, AB, Canada;(5) Division of Neurology, Walter Mackenzie Health Science Centre, University of Alberta, Edmonton, AB, Canada |
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| Abstract: | The mechanisms of action of the anticonvulsant topiramate (TPM) are indicative of a potential benefit during cerebral ischemia. TPM was studied in a transient global forebrain ischemia (TGFI) model in gerbils in which 40 mg/kg was administered before or after TGFI. Control groups were administered 0.9% normal saline similarly. The evaluation consisted of neurochemical, histological, and functional analyses. The data obtained indicates that unlike the focal cerebral ischemia model, TPM is not neuroprotective in TGFI. The difference in effect, which may be due to the difference in species or the type of ischemia, points to the need for caution when extrapolating animal data from this drug to humans. |
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| Keywords: | Topiramate hippocampus microdialysis gerbils neuroprotection histology |
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