Factors affecting the esterification of lipoprotein cholesterol by lecithin: cholesterol acyl transferase. |
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Authors: | J S David L A Soloff A G Lacko |
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Institution: | 1. Lipid Research Laboratory, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140, USA |
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Abstract: | Lecithin: Cholesterol Acyltransferase (LCAT) esterified relatively small amounts of cholesterol from very low density lipoproteins (VLDL), low density lipoproteins (LDL) or high density lipoproteins (HDL) in the presence of 5% human serum albumin (HSA). On the other hand, in the presence of very high density (>1.225 g/ml) plasma fraction (F-4), the enzyme esterified cholesterol from VLDL at considerably higher rates than from LDL or HDL. VLDL together with some component present in the very high density plasma fraction (F-4) may thus provide a highly efficient complex resulting in a favorable configuration of substrate lipids for the enzyme. |
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Keywords: | To whom requests for reprints should be directed |
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