Biokinetics of lead in various organs of rats using radiotracer technique |
| |
Authors: | Deepika Kaushal M L Garg M R Bansal M P Bansal |
| |
Institution: | (1) Department of Biophysics, Panjab University, 160014 Chandigarh, India |
| |
Abstract: | Uptake, distribution, and elimination of lead in various organs of rats have been studied using a radiotracer technique. The
elimination data for various organs, except whole blood, is fitted to a double-exponential function using a computer program.
The biological half-lives along with the percent elimination of lead by two different decay modes in testis, epididymis, prostate,
and seminal vesicles are being reported together with that in liver, kidney, blood, and whole body. It is evident from this
study that the elimination of lead is limited for all the organs and permits lead accumulation in the bone, where it is stored
and becomes almost unavailable for elimination. Lead levels in blood, testis, and femur of lead acetate-fed rats measured
using atomic absorption spectroscopy have been correlated to the uptake of210Pb in various organs. |
| |
Keywords: | 210Pb lead levels male rats reproductive organs biological half-life |
本文献已被 SpringerLink 等数据库收录! |
|