Baboon Virus Isolate M-7 with Properties Similar to Feline Virus RD-114 |
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| Authors: | Alfred Hellman Paul T Peebles James E Strickland Arnold K Fowler S S Kalter S Oroszlan and R V Gilden |
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| Institution: | National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014;Southwest Foundation for Research and Education, San Antonio, Texas 78206;Flow Laboratories, Inc., Rockville, Maryland 20852 |
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| Abstract: | A virus (M-7) isolated from baboon placental tissue demonstrates many similarities to endogenous feline virus RD-114. Immunodiffusion analysis shows a group-specific antigen (gs-1) line of identity between M-7 and RD-114. Anti-RD-114 DNA polymerase IgG inhibits M-7 polymerase by 57% compared to 97% for RD-114. M-7 virus has helper activity as demonstrated by rescue of murine sarcoma virus (MSV) from sarcoma-positive leukemia-negative human amnion cells. The host range of the rescued M-7 pseudotype of MSV, MSV (M-7), is similar to that of RD-114 virus. MSV (M-7) is also able to transform baboon cells and causes no detectable transformation of feline cells without addition of helper feline leukemia virus. Interference properties of M-7 and RD-114 virus are identical. Virus-specific neutralizing antisera, although partially cross-reacting, can distinguish MSV (M-7) from MSV (RD-114). These similarities and differences between RD-114 and M-7 viruses are best explained as type-specific differences between two viruses within the same strain. |
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