Microbial production of L-[15N]glutamic acid and its gas chromatography-mass spectrometry analysis |
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| Authors: | Z E Kahana A Lapidot |
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| Affiliation: | Department of Isotope Research, Weizmann Institute of Science, Rehovot, Israel |
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| Abstract: | L-[15N]Glutamic acid was prepared in high yields via a fermentative process. Brevibacterium lactofermentum, growing on a medium containing 97% enriched 15NH4Cl as a sole isotopic precursor, excreted mostly L-[15N]glutamic acid. The L-[15N]glutamic acid was purified and identified. Gas chromatography-mass spectrometry analysis was performed to demonstrate its usefulness in clinical studies. |
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| Keywords: | fermentation To whom correspondence should be addressed. |
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