Newly Detected Specific Hydrogenation of the Conjugated Double Bond of Unsaturated Alkaloid Lactones by Aspergillus sp. |
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| Authors: | Hong Guan Song You Li Yang Xu Wang Rui Ni |
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| Affiliation: | (1) Department of Biology & Chemistry, Shenyang Pharmaceutical University, 110016, Shenyang, P.R. China |
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| Abstract: | A new isolate of Aspergillus sp. hydrogenated the γ,δ-double bond of securinine (143 mg l−1) to give 14,15-dihydrosecurinine at over 98% (w/w) yield after 8 h. It also hydrogenated the C11(13) double bond of 3-hydroxy-1(10),3,11(13)-guaiatriene-12,6-olide-2-one (HGT) (200 mg l−1) to give 3-hydroxy-1(10),3-guaiadiene-12,6-olide-2-one with over 98% (w/w) conversion after 24 h. |
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| Keywords: | Aspergillus conjugated double bond reduction guaiatriene lactone lactones securinine |
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