Synthesis and its properties of oligonucleotide analogue containing thiocarbamate interlinkages. |
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Authors: | T Ohgi K Ishiyama H Tomi J Yano |
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Affiliation: | Research Laboratories, Nippon Shinyaku Co. Ltd, Kyoto, Japan. |
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Abstract: | Novel nucleotide analogues have been synthesized from morpholine subunits with thiocarbamate linkages. They indicated much stronger interaction with poly U or poly dT than the corresponding natural oligodeoxyribonucleotides. Solubility of the analogues in water was greatly enhanced by introducing sulfate groups at their both ends. |
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