The effect of anions and cations on cardiac adenylate cyclase: interactions with isoprenaline and GTP |
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| Authors: | L Leclerc S E Harding P Harris |
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| Institution: | Cardiothoracic Institute, University of London 2, Beaumont Street, London, W1N 2DX, UK |
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| Abstract: | The level of actin was found to decrease markedly when ataxia telangiectasia lymphoblastoid cells were stepped from low to high density culture conditions. Additionally, as the actin levels decreased the levels of a protein species of 37K daltons increased by orders of magnitude. Partial proteolytic digestion of the 37K protein and actin revealed that the primary structures of these proteins were not related. This phenomena was observed in three out of four ataxia telangiectasia lymphoblastoid cell lines but not in lymphoblastoid cells derived from normal individuals. |
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