State of the opioid system in rats with different sensitivity to ethanol |
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Authors: | Pivovarchik M V |
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Institution: | Institute of Biochemistry, National Academy of Sciences of Bylarus, Grodno. val@biochem.unibel.by |
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Abstract: | In this work we investigated the content of opioids in plasma blood and the changes caused by ethanol (1.5 g/kg, i.p.) in midbrain opioid receptors of rats with different sensitivity to ethanol, as determined according to the duration of ethanol-induced sleep (DEIS). A receptor binding technique with selective delta-DADLE and mu-DAGO radioligands were used. Ethanol even at low dose produced changes in the midbrain opioid receptors which appeared after 6 hours. The response of the receptors and the content of opioids in plasma blood of rats with different DEIS were not identical. |
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