The effect of amino acids on the survival of the hyperthyroid rat |
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| Authors: | BOLDT R E HARPER A E ELVEHJEM C A |
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| Affiliation: | 1. Key Laboratory of Photochemistry, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;1. Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai, 200090, China;2. Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Instituto de Agroecoloxía e Alimentación (IAA) – CITEXVI, 36310, Vigo, Spain;3. Institute of Pediatrics, Children''s Hospital of Fudan University, Fudan University, Shanghai, 200032, China;4. Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science & Technology Center, Chengdu, 610213, China;5. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212016, China;1. Institute of Molecular Biology and Biotechnology, FORTH, 70013 Herakleion, Crete, Greece;2. Department of Biochemistry and Biotechnology, University of Thessaly, Larissa 41500, Greece;3. Ionis Pharmaceuticals, Carlsbad, CA, USA;4. Department of Biology, University of Crete, 70013 Herakleion, Crete, Greece;1. Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, 712100, China;2. German Institute of Human Nutrition (DIfE) Potsdam-Rehbruecke, Department of Molecular Toxicology, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany;3. German Center for Diabetes Research (DZD), 85764, Muenchen-Neuherberg, Germany;4. NutriAct-Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany;5. German Center for Cardiovascular Research (DZHK), Berlin, Germany;6. Institute of Nutrition, University of Potsdam, Nuthetal, 14558, Germany |
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| Abstract: | Methionine, added to a casein diet which is complete for normal rats, markedly increases the survival time of hyperthyroid rats. That the improved survival is due to the labile methyl group of methionine is supported by the fact that betaine, another labile methyl-containing compound, also increases the survival time of hyperthyroid rats. |
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