Isolation and initial characterization of the mouse Dnmt3l gene |
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| Authors: | Aapola U Lyle R Krohn K Antonarakis S E Peterson P |
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| Affiliation: | Institute of Medical Technology, University of Tampere, and Tampere University Hospital, Tampere, Finland. ulla.aapola@uta.fi |
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| Abstract: | We have isolated and sequenced the mouse zinc finger gene, Dnmt3l (DNA cytosine-5-methyltransferase 3-like), on mouse chromosome 10, showing similarity to members of the DNMT3/Dnmt3 family. The Dnmt3l protein contains an ADD zinc finger, which Dnmt3l shares with other Dnmt3 family members and Atrx. RT-PCR analysis showed Dnmt3l expression in testis, thymus, ovary, and heart, as well as in 7-day, 15-day, and 17-day mouse embryos. |
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