Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells |
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Authors: | Yoon Hoon-Seok Lee Sun-Ryung Ko Hee-Chul Choi Soo-Youn Park Ji-Gweon Kim Jeong-Kook Kim Se-Jae |
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Institution: | Technology Innovation Center for Life Science, Cheju National University, Jeju, Korea. |
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Abstract: | Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression. |
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