Regulation of bacteriophage Mu transposition |
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Authors: | Ariane Toussaint Marie-José Gama Jamal Laachouch Geneviève Maenhaut-Michel Amina Mhammedi-Alaoui |
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Institution: | (1) Laboratoire de Génétique, Université Libre de Bruxelles, B1640 Rhode St Genèse, Belgium;(2) Laboratoire de Biochimie des Micro-organismes, Université J. Fourier, BP53, 38041 Grenoble cedex 9, France |
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Abstract: | Bacteriophage Mu is a transposon and a temperate phage which has become a paradigm for the study of the molecular mechanism of transposition. As a prophage, Mu has also been used to study some aspects of the influence of the host cell growth phase on the regulation of transposition. Through the years several host proteins have been identified which play a key role in the replication of the Mu genome by successive rounds of replicative transposition as well as in the maintenance of the repressed prophage state. In this review we have attempted to summarize all these findings with the purpose of emphasizing the benefit the virus and the host cell can gain from those phage-host interactions. |
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Keywords: | Clp protease histone-like proteins phage Mu transposition |
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