Assignment of the human tyrosine aminotransferase gene to chromosome 16 |
| |
Authors: | E Natt F-T Kao R Rettenmeier G Scherer |
| |
Institution: | (1) Institut für Humangenetik der Universität, Albertstrasse 11, D-7800 Freiburg i. Br., Federal Republic of Germany;(2) Eleanor Roosevelt Institute for Cancer Research, and Department of Biochemistry, Biophysics and Genetics, University of Colorado School of Medicine, 80262 Denver, CO, USA |
| |
Abstract: | Summary The liver enzyme tyrosine aminotransferase (TAT; EC 2.6.1.5) catalyzes the rate-limiting step in the catabolic pathway of tyrosine. Deficiency in TAT enzyme activity underlies the autosomally inherited disorder tyrosinemia II (Richner-Hanhart syndrome). Using a human TAT cDNA clone as hybridization probe, we have determined the chromosomal location of the TAT structural gene by Southern blot analysis of DNAs from a series of human x rodent somatic cell hybrids. The results assign the TAT gene to human chromosome 16. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|