Differential accessibility at the kappa chain locus plays a role in allelic exclusion |
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Authors: | Goldmit Maya Schlissel Mark Cedar Howard Bergman Yehudit |
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Institution: | The Hubert H.Humphrey Center for Experimental Medicine and Cancer Research, Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel. |
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Abstract: | Gene rearrangement in the immune system is always preceded by DNA demethylation and increased chromatin accessibility. Using a model system in which rearrangement of the endogenous immunoglobulin kappa locus is prevented, we demonstrate that these epigenetic and chromatin changes actually occur on one allele with a higher probability than the other. It may be this process that, together with feedback inhibition, serves as the basis for allelic exclusion. |
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