Plasma Factor in Red Blood Cells Adhesion to Endothelial Cells: Humans and Rats |
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| Authors: | Avraham Schlager Gideon Zamir Gregory Barshtein Saul Yedgar Dan Arbell |
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| Institution: | (1) Surgery Department, New York University Hospital, New York, NY, USA;(2) Surgery Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel;(3) Department of Biochemistry, The Faculty of Medicine, The Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel;(4) Pediatric Surgery Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel; |
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| Abstract: | Erythrocyte adhesion to the vascular endothelium is one of the key determinants of microcirculatory blood flow. Adhesion is
a complex process determined by the intricate interaction among red blood cells (RBC), plasma factors, and the vascular endothelium.
Rats are commonly used as disease models to investigate the pathophysiology of various hematological disease processes occurring
in humans and their response to prospective treatments. The aim of our study was to characterize the adhesion of RBC in adult
blood from rat and human subjects, in order to test the validity of rat models for adhesion-related disease processes. We
demonstrated that adhesion of RBC from rats (rRBC), to endothelial cells (EC) in plasma-free buffer, is stronger than from
human subjects (hRBC). In addition, plasma proteins induced elevation of hRBC (eightfold) but depression of rRBC (threefold)
adhesion to EC. It is thus suggested to be aware of the difference in RBC/EC interaction for human and rat subjects, when
studying models of blood flow. |
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