Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection |
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| Authors: | Saugata Mahapatra Patricia Ayoubi Edward I Shaw |
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| Affiliation: | (1) Department of Microbiology and Molecular Genetics, Oklahoma State University, State University of Campinas, 307 Life Sciences East, 74078 Stillwater, OK, USA;(2) Department of Biochemistry and Molecular Biology, Oklahoma State University, 246C Noble Research Center, 74078 Stillwater, OK, USA |
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| Abstract: | Background Coxiella burnetii is an intracellular bacterial pathogen that causes acute and chronic disease in humans. Bacterial replication occurs within enlarged parasitophorous vacuoles (PV) of eukaryotic cells, the biogenesis and maintenance of which is dependent on C. burnetii protein synthesis. These observations suggest that C. burnetii actively subverts host cell processes, however little is known about the cellular biology mechanisms manipulated by the pathogen during infection. Here, we examined host cell gene expression changes specifically induced by C. burnetii proteins during infection. |
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