SOS induction by stabilized topoisomerase IA cleavage complex occurs via the RecBCD pathway |
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| Authors: | Sutherland Jeanette H Cheng Bokun Liu I-Fen Tse-Dinh Yuk-Ching |
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| Institution: | Department of Biochemistry and Molecular Biology, Basic Science Building, New York Medical College, Valhalla, NY 10595, USA. |
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| Abstract: | Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA. |
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