Cerebral ischemia: Changes in monoamines are independent of energy metabolism |
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| Authors: | B B Mrsulja B M Djuricic Y Ueki W D Lust M Spatz |
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| Institution: | (1) Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, 20892 Bethesda, Maryland;(2) Laboratory for Neurochemistry National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, 20892 Bethesda, Maryland;(3) CVD Research Group, Institute of Biochemistry, School of Medicine, Belgrade, Yugoslavia;(4) International Fogarty Fellow From CVD Research Group, Institute of Biochemistry, School of Medicine, Belgrade, Yugoslavia;(5) Division of Experimental Neurosurgery, Case Western Reserve University, 44106 Cleveland, Ohio;(6) NIH, NINCDS/LNNS, Bldg. 36. Room 4D04, 20892 Bethesda, MD |
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| Abstract: | The relationship of neurotransmitters and neuroeffectors to the energy state of the brain was examined in the gerbil model of ischemia after 5 and 15 min of bilateral common carotid artery occlusion only or with 1 hr of reperfusion. The gerbil brains were fixed by microwave irradiation and a total of 15 metabolites were measured from a single piece of tissue from either the hippocampus or the striatum. The rapid alterations in energy-related compounds and cyclic nucleotides appeared to be directly related both to the loss of oxygen and glucose during ischemia and the resupply of these nutrients during reflow. Significant reduction in the level of monoamines occurred prinicipally during reflow, at a time when the energy-related metabolites were restored. It is proposed that the changes in monoamines were triggered by other ischemic-induced events unrelated to energy depletion.Presented in part at the Nineteenth Annual Meeting of the American Society for Neurochemistry, 1988 |
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| Keywords: | Cerebral ischemia energy metabolism monoamines |
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