Inhibitory effect of somatostatin on human pancreatic polypeptide secretion |
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Authors: | José Marco JoséA. Hedo María L. Villanueva |
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Affiliation: | Clínica Puerta de Hierro, Universidad Autónoma de Madrid, Madrid-35, Spain |
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Abstract: | In this work we have investigated the effect of somatostatin on the secretion of human pancreatic polypeptide (HPP). In a group of five gastrectomized patients, somatostatin infusion induced a significant decline of fasting HPP plasma levels and completely abolished HPP response to oral glucose. Upon somatostatin withdrawal, HPP concentrations returned to pre-experimental values. These data add a new hormone to the list of those inhibited by somatostatin. |
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