Morphine addiction and withdrawal alters brain peptide concentrations |
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| Authors: | J E Morley T Yamada J H Walsh C B Lamers H Wong A Shulkes D A Damassa J Gordon H E Carlson J M Hershman |
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| Institution: | Endocrine Research Laboratory, Wadsworth VA Hospital and Center for Ulcer Research and Department of Medicine, University of California, Los Angeles, California, USA |
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| Abstract: | This study demonstrates that, during morphine addiction and withdrawal in rats profound alterations in the concentrations of a variety of brain peptides occur. Somatostatin, cholecystokinin, neurotensin and substance P concentrations increased during morphine addiction. Naloxone-induced withdrawal decreased brain concentrations of TRH, somatostatin, neurotensin and substance P. Naloxone alone decreased thalamic substance P and neurotensin concentrations. Vasoactive intestinal peptide concentrations were unaltered by any of the treatments. The fall in the tissue concentration of somatostatin during naloxone-induced withdrawal correlated well with the fall in the circulating growth hormone, suggesting that this could be secondary to somatostatin release. Our data support the hypothesis that brain peptides, acting locally in the brain as neuromodulators, play an important role in the genesis of the syndromes of morphine addiction and withdrawal. |
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| Keywords: | Address correspondence to: J E Morley MB BCh Neuroendocrine Research Laboratory Minneapolis VA Hospital Minneapolis MN 55417 U S A |
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