Isolation and microsequence analysis of a novel form of neuromedin U from guinea pig small intestine |
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| Authors: | R Murphy C A Turner J B Furness L Parker A Giraud |
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| Institution: | Department of Anatomy and Histology, School of Medicine, Flinders University, Bedford Park, S.A., Australia. |
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| Abstract: | A multidimensional chromatographic regimen has been used to isolate and purify a peptide showing immunoreactivity for neuromedin U from guinea pig small intestine. Microsequence Edman N-terminal analysis and C-terminal analysis by enzymatic digestion showed this peptide to be a nonapeptide with the following sequence: H-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2. The C-terminal octapeptide of this sequence is the same as porcine NMU-8, and the C-terminal heptapeptide is identical to rat NMU(17-23). |
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