Diversity and evolution of MicroRNA gene clusters |
| |
Authors: | YanFeng Zhang Rui Zhang Bing Su |
| |
Institution: | (1) State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China |
| |
Abstract: | microRNA (miRNA) gene clusters are a group of miRNA genes clustered within a proximal distance on a chromosome. Although a
large number of miRNA clusters have been uncovered in animal and plant genomes, the functional consequences of this arrangement
are still poorly understood. Located in a polycistron, the coexpressed miRNA clusters are pivotal in coordinately regulating
multiple processes, including embryonic development, cell cycles and cell differentiation. In this review, based on recent
progress, we discuss the genomic diversity of miRNA gene clusters, the coordination of expression and function of the clustered
miRNAs, and the evolutionarily adaptive processes with gain and loss of the clustering miRNA genes mediated by duplication
and transposition events.
Supported by State Key Program of National Natural Science of China(Grant No. 306300130) |
| |
Keywords: | microRNA gene clusters gene duplication adaptive evolution transposition |
本文献已被 CNKI SpringerLink 等数据库收录! |
| 点击此处可从《中国科学:生命科学英文版》浏览原始摘要信息 |
| 点击此处可从《中国科学:生命科学英文版》下载免费的PDF全文 |
|