Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue |
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| Authors: | Konno Hiroyuki Hiura Naoki Makabe Hidefumi Abe Masato Miyoshi Hideto |
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| Affiliation: | Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, 2-1Minamijosanjima-cho, Tokushima 770-8506, Japan. konno@bio.tokushima-u.ac.jp |
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| Abstract: | To elucidate the inhibitory action of acetogenins, we synthesized an acetogenin derivative which possesses tetraol in place of the tetrahydrofuran ring and examined its inhibitory activity against bovine heart mitochondrial complex I. Our results indicate that these hydroxy groups are an essential structural factor though it is not effective as bis-THF hydroxy groups combination. |
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