Strain improvement inStreptomyces galilaeus,a producer of anthracycline antibiotics galirubins |
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Authors: | E Královcová M Blumauerová Z Vaněk |
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Institution: | (1) Department of Biogenesis of Natural Compounds, Institute of Microbiology, 142 20 Prague 4 |
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Abstract: | The production of ε-pyrromycinone glycosides inStreptomyces galilaeus increased 12-fold, with respect to the wild strain, as a result of a sequential procedure including both natural selection
and treatment with mutagens (nitrous acid, UV light and γ-irradiation). Nitrous acid exhibited the highest mutagenic effect,
both in increasing the productivity and in inducing blocked mutants. A mutant strain blocked in the biosynthesis of glycosides
and accumulating free ε-pyrromycinone as the principal metabolite was obtained. |
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