Sequence analysis of an amphioxus cosmid containing a gene homologous to members of the aldo-keto reductase gene superfamily |
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Authors: | Boeddrich A Burgtorf C Francis F Hennig S Panopoulou G Steffens C Borzym K Lehrach H |
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Affiliation: | Max Planck Institut für Molekulare Genetik, Ihnestr. 73, D-14195 Berlin (Dahlem), Germany |
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Abstract: | To gain an insight into vertebrate genome evolution, we have analysed the organization of an approximately 40-kb genomic clone of an amphioxus (Branchiostoma floridae) cosmid library. Amphioxus is considered as being the last non-vertebrate relative to vertebrates. Sequencing and analysis of the above clone using three different exon prediction programs (Grail, GenScan, Mzef) have led to the identification of a gene of the aldo-keto reductase family as well as further exons that gave a significant database match to known genes. |
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Keywords: | Cosmid sequencing Exon prediction Expressed sequences |
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