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Atypical Micromorphology and Uncommon Location of Cryptococcosis: A Histopathologic Study Using Special Histochemical Techniques (One Case Report) |
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| Authors: | Alexandra Flávia Gazzoni Cecília Bittencourt Severo Marines Bizarro Barra Luiz Carlos Severo |
| Institution: | (1) Post-graduation Program in Pulmonary Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;(2) Clinical Mycology Laboratory, Complexo Hospitalar Santa Casa, Annes Dias, 285, 90020-090 Porto Alegre, RS, Brazil;(3) Department of Pathology, Complexo Hospitalar Santa Casa, Porto Alegre, RS, Brazil;(4) Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil |
| Abstract: | Here we report an unusual case of disseminated cryptococcosis in a patient with AIDS. Although typical Cryptococcus neoformans micromorphology was observed in tongue biopsy, cervical lymph node examination revealed atypical histopathologic findings. These included pseudohyphae, chains of budding yeasts and structures resembling germ tubes. Cryptococcus neoformans infection in supraclavicular lymph nodes was also confirmed by culture. The importance of using special histochemical techniques—Mayer’s mucicarmine stain for mucicarminophilic capsule and Grocott’s silver stain—in the diagnosis of cryptococcosis is reinforced. |
| Keywords: | Cryptococcus neoformans Pseudohyphae Lymphadenitis Mayer’ s mucicarmine stain Grocott’ s silver stain |
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