On the nature of mutations in molecular evolution |
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Authors: | María ANGÉLICA SOTO José Tohá |
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Institution: | (1) Departamento de Física. Fac. Ciencias Físicas y Matemáticas., Universidad de Chile.Casilla, 487-3 Santiago, Chile |
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Abstract: | In this work it is proposed that in evolution amino acid substitutions implying strong physico chemical and structural differences are more relevant and more frequent than substitutions between similar amino acids. This analysis is made over a group of protein families representing about 10 000 substitutions and as examples the evolutionary trees of fibrinopeptides A and calcitonins were constructed and compared. |
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