The evolutionarily conserved MOS4-associated complex |
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Authors: | Kaeli C M Johnson Oliver X Dong Xin Li |
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Institution: | (1) Laboratory of Plant Molecular Genetics, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0101, Japan;(2) Laboratory of Genetic Engineering, College of Life Sciences, South China Agricultural University, Guangzhou, 510642, China |
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Abstract: | Recent work in plant immunity has shown that MOS4, a known intermediate in R protein mediated resistance, is a core member
of the nuclear MOS4-associated complex (MAC). This complex is highly conserved in eukaryotes, as orthologous complexes known
as the CDC5L-SNEVPrp19-Pso4 complex and the Nineteen complex (NTC) were previously identified in human and yeast, respectively. The involvement of these
complexes in pre-mRNA splicing and spliceosome assembly suggests that the MAC probably has a similar function in plants. Double
mutants of any two MAC components are lethal, whereas single mutants of the MAC core components mos4, Atcdc5, mac3, and prl1 are all viable and display pleiotropic defects. This suggests that while the MAC is required for some essential biological
function such as splicing, individual MAC components are not crucial for complex functionality and likely have regulatory
roles in other biological processes such as plant immunity and flowering time control. Future studies on MAC components in
Arabidopsis will provide further insight into the regulatory mechanisms of the MAC on specific biological processes. |
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