Sequence analyses of cyanobacterial bicarbonate transporters and their homologues |
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Authors: | von Rozycki Torsten Schultzel Mark A Saier Milton H |
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Institution: | Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0116, USA. |
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Abstract: | The primary HCO3- uptake system in the cyanobacterium Synecocystis is the Na+-dependent transporter SbtA. SbtA and its homologues were identified and shown to display a common topology of ten transmembrane segments (TMSs). These proved to have arisen by an intragenic duplication event from an ancestral gene encoding a five TMS protein product. A region of SbtA shows sufficient similarity to 10 TMS ABC-type integral membrane transport proteins to suggest a common origin. Phylogenetic analyses of the SbtA family revealed two clusters of cyanobacterial homologues with all non-cyanobacterial family members outside of these two clusters. The tree topology suggests that SbtA family members display multiple transport functions. |
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