TRIMming Flavivirus infection |
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| Authors: | Gack Michaela U |
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| Institution: | Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA. michaela_gack@hms.harvard.edu |
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| Abstract: | Tripartite motif (TRIM) proteins are novel players in antiviral innate immunity. In this issue of Cell Host & Microbe,Taylor et?al. (2011) discover the mechanism of action of TRIM79α and show that this interferon-induced protein restricts tick-borne flaviviruses by targeting the viral polymerase for degradation. |
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