Real-time quantitative analysis of the influence of blue light on citrinin biosynthetic gene cluster expression in Monascus |
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| Authors: | Wang Changlu Yang Hua Chen Mianhua Wang Yurong Li Fengjuan Luo Cheng Zhao Shuyi He Dong |
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| Institution: | Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology, Tianjin University of Science & Technology, No. 29, the 13th Avenue, TEDA, Tianjin, 300457, People's Republic of China, changluwang2009@gmail.com. |
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| Abstract: | When Monascus MX was grown under blue light instead of in the dark, citrinin production increased from 478?mg?l(-1) to 698?mg?l(-1). To explain this, the expression of the pksCT gene, which encodes citrinin polyketide synthase, and of 5 ORFs around it, were monitored. Blue light enhanced citrinin production by upregulating the expression of orf1, orf3, and orf4, indicating that pksCT was not the key gene responsible for the quantity of citrinin production in blue light. |
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