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Proteomics discovery of chemoresistant biomarkers for ovarian cancer therapy |
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| Authors: | Junli Deng Li Wang Jie Ni Julia Beretov Valerie Wasinger Duojia Wu |
| Affiliation: | 1. Cancer Care Centre, St George Hospital, Kogarah, Australia;2. St George and Sutherland Clinical School, University of New South Wales (UNSW), Kensington, Australia;3. Department of Gynecological Oncology, Henan Cancer Hospital, Zhengzhou, China;4. Zhengzhou University, Zhengzhou, China;5. Department of Gynecological Oncology, Henan Cancer Hospital, Zhengzhou, China;6. Mark Wainwright Analytical Centre, Bioanalytical Mass Spectrometry Facility, University of New South Wales (UNSW), Kensington, Australia;7. School of Medical Sciences, University of New South Wales (UNSW), Kensington, Australia |
| Abstract: | Introduction: Chemoresistance is a major challenge to current ovarian cancer chemotherapy. It is important to identify biomarkers to distinguish chemosensitive and chemoresistant patients. Areas covered: We review the medical literature, discuss MS-based technologies with respect to chemoresistant ovarian cancer and summarize the promising chemoresistant biomarkers identified. In addition, the challenges and future perspectives of biomarker discovery research are explored. With the employment of mass spectrometry-based (MS-based) proteomics, biomarker discovery of ovarian cancer has made great progress in the last decade. Many potential biomarkers were identified by MS-based proteomics technologies, some of which have been validated for further extensive studies in clinical settings. Expert commentary: The discovery of chemoresistant biomarkers is a newly developing area and may provide a clue for predicting chemotherapeutic response and discover therapeutic targets for paving the way of personalized medicine. Multiple complementary MS-based proteomics approaches hold promise for finding novel therapeutic targets in ovarian cancer treatment. |
| Keywords: | Mass spectrometry ovarian cancer proteomics chemoresistance biomarker |