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Mapping and analyzing the human liver proteome: progress and potential |
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| Authors: | Hongxiu Yu Fang Wang Ling Lin Weiqian Cao Yinkun Liu Lunxiu Qin |
| Affiliation: | 1. Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China;2. Minhang Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China;3. China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China |
| Abstract: | Introduction: The liver is an important organ in humans. Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world. Progress in the Human Liver Proteome Project (HLPP) has improved understanding of the liver and the liver cancer proteome. Areas covered: Here, we summarize the recent progress in liver proteome modification profiles, proteomic studies in liver cancer, proteomic study in the search for novel liver cancer biomarkers and drug targets, and progress of the Chromosome Centric Human Proteome Project (CHPP) in the past five years in the Institutes of Biomedical Sciences (IBS) of Fudan University. Expert commentary: Recent advances and findings discussed here provide great promise of improving the outcome of patients with liver cancer. |
| Keywords: | Liver liver cancer metastasis proteomics glycosylation biomarker |