Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides |
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Authors: | Yi-ning Wen Zhi-feng Zhang Ning-ning Liu Yu-hong Xiang Zhuo-yong Zhang Graciela Andrei |
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Institution: | 1. Department of Applied Chemistry and Pharmaceutics, Beijing Institute of Technology, Beijing 100081, China;2. Department of Chemistry, Capital Normal University, Beijing 100048, China;3. Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium |
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Abstract: | A series of novel trisubstituted 1,2,3-triazole purine nucleosides were efficiently synthesized via Huisgen 1,3-dipolar cycloaddition in good yields. Bioactivity against cytomegalovirus (CMV) and varicella-zoster virus (VZV) in human embryonic lung cell cultures was evaluated and all compounds show low antiviral activity. |
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Keywords: | triazole nucleosides Huisgen 1 3-dipolar cycloaddition antiviral |
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