|
|||||
|
|
Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death |
|
| Authors: | Lorente Mar Torres Sofia Salazar María Carracedo Arkaitz Hernández-Tiedra Sonia Rodríguez-Fornés Fátima García-Taboada Elena Meléndez Bárbara Mollejo Manuela Campos-Martín Yolanda Barcia Juan A Guzmán Manuel Velasco Guillermo |
| Affiliation: | Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain. |
| Abstract: | Δ?-tetrahydrocannabinol (THC), the main active component of marijuana, promotes cancer cell death via autophagy stimulation. We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |